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Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation

In arriving at our criteria we consulted three standard textbooks of medicine (Alstead, Davidson and Price), a consultant haematologist, the librarian at the Royal College of General Practitioners, and the Monthly Index of Medical Specialities

twice-daily keeps tissue concentration steadier

They are often used for people who have difficulty absorbing B12 from food or supplements due to conditions like pernicious anemia, gastrointestinal disorders (e.g., Crohns disease, celiac disease), or after certain surgeries (e.g., gastric bypass)

History First synthesized in the early 1990s by researchers investigating cytoprotective proteins found in gastric juice

Fox notes