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Mookkan et al., 2017), transgene-free genome editing (Zhang et al., 2025b), the synthetic apomictic sorghum (Simon et al., 2025), and nanobiotechnology in sorghum (Yong et al., 2025), has greatly facilitated basic sorghum research and industrial applications in recent years

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Crucially, empirical attempts to overcome this by combinatory treatment have often failed to improve overall survival, demonstrating that the barrier to adaptive resistance is not easily circumvented by simple combination strategies [86]

Together, the stack addresses both energy expenditure (AMPK) and fat accumulation (NNMT inhibition), creating synergistic metabolic effects that neither compound produces alone

Immunoblot detection of lipoylation and glutarylation relies on antibody specificity