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Le foie est l'organe le plus fortement impliqu dans la dtoxification des xnobiotiques (substances trangres l'organisme)

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NHK is encoded by a nonsense mutation of 1-antitrpysin that results in a truncated product which is retained in the ER and undergoes ER-associated degradation, resulting in ER stress in diverse cell types (Nagasawa, Higashi, Hosokawa, Kaufman, & Nagata, 2007

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