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Circulating glutathione is primarily cleared by the kidney

[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Taliou A., Zintzaras E., Lykouras L., Francis K

For more than a century, methylene blue (MB), a tricyclic phenothiazine often referred to as methylthionine hydrochloride, has been used for a variety of medical purposes, including targeting specific cellular targets

For instance, PM2.5 has been shown to contribute to endothelial dysfunction and DNA methylation changes, linking vascular injury with tumorigenic processes

These indicate the intriguing role of ISA-induced autophagy in its cell death-stimulating effects, which needs further deep exploration