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found that patients with T2DM, hyperlipidemia, coronary artery disease, polycystic ovary disease (PCOD), or obesity, and on metformin therapy were significantly associated with increased risk of vitamin B 12 deficiency and lower serum vitamin B 12 concentrations [9]

(1993) Metabolic effects of rhIGF-1 in normal human subjects

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[DOI] [PubMed] [Google Scholar] 110.Porto LC, Alves Azizi MA, Pelajo-Machado M, Matos da Silveira PR, Lenzi HL

Women tend to experience more gastrointestinal side effects at each dose level in clinical trial data, though the difference is not large enough to warrant a different escalation schedule