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Liu X, Yi M, Jin R, Feng X, Ma L, Wang Y, et al

In the absence of MTAP, the substrate methyl thionyl adenosine (MTA) accumulates and acts as a selective inhibitor of PRMT5 to inhibit PRMT5 methylation activity, 237 whereas MAT2A can produce the PRMT5 substrate SAM, 238 allowing PRMT5 to exert its oncogenic effect

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Safety and tolerability Finding: No serious adverse events were reported in either group

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