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When Eli Lilly designed the Phase 2 clinical trial that put Retatrutide on the map, they tested four different dose groups (1mg, 4mg, 8mg, and 12mg) alongside a placebo group

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doi: 10.1158/1078-0432.CCR-14-0695

In preclinical data, the pair improves adipocyte NAD+ by inhibiting NNMT, resulting in better fat metabolism and reduced obesity.[8][3] For anti-aging, this translates to improved tissue resilience and reduced senescence