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conducted prospective and retrospective observational studies on the efficacy of the combination of duloxetine (DLX) and pregabalin (PGB) for the treatment of FM syndrome, and the possibility of additional benefits with the addition of the lipid signaling molecule palmitoylethanolamide (PEA) [59]

This will lower the burden on your metabolic systems and will limit acetaldehyde accumulation - the key factor in hangover development

Side Effects Due to the paucity of studies done in humans thus far, there is also limited data regarding safety and associated side effects

doi: 10.1038/labinvest.3700355

No tumor findings were observed in male mice at doses up to 255 mcg/kg/day (approximately 455-fold the RHDID on an AUC basis)