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In one study, hypomethylated genes included ITGA9, encoding an integrin and other relevant genes such as ADAM12, COL23A1, COL4A2, and MYO1E, and transcription factors genes RUNX1, RUNX2, and RUNX3 were hypomethylated in both dSSc and lSSc

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10.1016/j.jsams.2019.06.013 196 MattssonN.TosunD.InselP

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Given the fact that vitamin B12 levels were increased insignificantly among all routes, the preference of the administrated route should be referenced to the advantages and disadvantages of each route as well as the patient situation, which will be decided according to the physicians opinion