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While nosebleeds are not a common safety signal, baseline risk stratification ensures individualized monitoring and early intervention if epistaxis develops

The resting state of RAW264.7 cells were polarized into M1 or M2 cells by the addition of LPS (100 ng/mL, Sigma-Aldrich) and IFN- (20 ng/mL, R&D systems) for 24 h or M-CSF (20 ng/mL, R&D Systems), IL-4 (40 ng/mL, R&D Systems), and IL-13 (40 ng/mL, R&D Systems) for 6 days, respectively

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