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Exp Clin Endocrinol Diabetes 2022, 130, 358367
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importantly, this action appears to be mediated by ROS/RNS 24
The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default
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The spectrum is shown in black and integrated to R~100
