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Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate

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noted an antidepressant-like effect on both wildtype and Huntington-disease murine models, which was noted to be due to decreased mitochondrial oxidative stress [33]

Keywords: depression, oxidative stress, glutathione, magnetic resonance spectroscopy, mood, biomarker 1

Am J Physiol Cell Physiol 2003

This increased demand for oxygen supply causes oxidative stress and, ultimately, muscle damage