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663 Long non-coding RNAs (lncRNAs), such as NONRATT021972, may regulate pain signaling pathways and are potential therapeutic targets

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Acknowledgements Christopher Udoye and Rudolf Manz were supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) MA 2273/16-1

How Epithalon Works: Mechanisms of Action Epithalons longevity-promoting effects come from several interconnected biological mechanisms: Activates telomerase maintains telomere length and cellular youthfulness Stimulates pineal gland increases melatonin production and regulates circadian rhythm Reduces oxidative stress neutralizes free radicals and DNA damage Normalizes immune activity promotes immune balance and thymus function Regulates gene expression modifies age-related gene activity via epigenetic pathways These systemic benefits help Epithalon restore balance in multiple organ systems at once

Organoids were optically cleared in a glycerolfructose clearing solution before imaging