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Furthermore, estrogen deficiency alters the profile of circulating signals from adipose, skeletal muscle, and the gut microbiome to stimulate hepatic inflammation and MASLD development (Fig
PMID: 33681815
Specifically, the relative abundance of Desulfobacterota doubled in the anterior region, while the levels of Firmicutes increased and Proteobacteria, Actinobacteriota, and Campylobacterota were reduced in the posterior region when supplementing the diet with bile salts (Ruiz et al., 2023)

Specific hereditary backgrounds are implicated, such as FOXP3 pathogenic variants in immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and autoimmune regulator (AIRE) mutations in APS type 1 (Klubo-Gwiezdzinska And Wartofsky 2022)
Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis
These findings provide novel insights for precision medicine approaches in SLE management, particularly for refractory cases that respond poorly to conventional therapies
