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Collectively, these data indicate that combined loss of PHD2 and GSTP1 precipitates a metabolic and apoptotic collapse consistent with a synthetic lethal interaction
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When considering drugs with a high addiction or dependence potential, those with a short half-life are typically harder to withdraw from than those with a long half-life
GPX4 genetic knockdown mirrored RSL3 effect on mTOR pathway suppression
GSH depletion in rats affects mitochondrial function during liver regeneration, resulting in diminished liver regeneration [40]
