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Erastin induces considerable apoptosis and reduces the growth capacity of metastatic colorectal cancer, with IC50 values 3-fold lower compared with those of sulfasalazine (SASP), which suggested that erastin is more effective compared with SASP (54)

Besides cancer cells and T cells, the TME is comprised of many other immune and non-immune cells, including stromal cells (like cancer associated fibroblasts (CAFs)), blood vessels, neurons, and extracellular matrix (ECM)

The peptide should dissolve into a clear, colourless solution within a minute or two

10.1073/pnas.1609980114 Proc

Latino D, Venditti M, Falvo S, Grillo G, Santillo A, Messaoudi I, et al

Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage
