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10.1016/j.drugalcdep.2017.08.034 67 SmithK

121 While degenerative IVDs can secrete many inflammatory and pain mediators, including TNF-, IL-1, IL-6, IL-8, substance P, and prostaglandin E2, these factors not only reduce proteoglycan and collagen synthesis but also stimulate nerve fiber ingrowth and induce pain

Some users swear by them, others are more cautious

MorelliMGalluzzoMMadonnaSScarponiCScaglioneGLGalluccioTet al

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Anti-depressive effects in animal studies
