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Evans et al, 1997

In a murine model, MO was genotoxic at supra-supplementation levels of 3,000 mg/kg body weight (39)

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it does not prove a visible, durable human result

The MTHFR 1298AC mutation is also present in about 25% of the global population, occurring most frequently in those of South East Asian descent (42%) and Europeans (31%)