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The inferior area postrema is at the foramen of Magendie

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While these studies provided evidence for a paradigm shift in the role of JNK in APAP hepatotoxicity, there are some reservations that need to be further explored before discarding a role for JNK in APAP-induced liver injury

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Sci Rep 7(1):112 Chaccour C, Lines J, Whitty CJM

This is due to free radicals-induced MT-transcriptional responses through metal regulatory transcription factor 1 (MTF-1) which in the presence of Zn ions (displaced from SOD by cadmium contained in cigarette smoke), binds to a metal-responsive element in the promoter region of the MT gene to initiate its transcription (Wolfram et al