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This triggers the release of DAMPs, which activate TLR/NF-B signaling in macrophages to promote M1 polarization
Additionally, exogenous, infectious factors occurring locally (including infections), dietary factors (improper diet), psychogenic factors (stress), and atmospheric factors (sun, humidity, cold) may participate in the development of rosacea

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These results indicate that NNMT activities are increased in the development of T2D
