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Secondly, under drug stress, the fungus undergoes core metabolic remodeling, with the activities of glycolysis and the tricarboxylic acid cycle being downregulated, and the cells entering a low metabolism and non-proliferative dormant state, significantly reducing their sensitivity to lethal doses of antifungal drugs

HP 13 C MR via dissolution dynamic nuclear polarization (dDNP) is an emerging imaging technology that allows direct visualization of metabolic conversion of 13 C-enriched molecules, and has been applied extensively to study metabolism in cells, tissues, animal models, and patients 22,23,24

The antioxidant system In the face of oxidative damage caused by iron overload, intracellular antioxidant systems prevent cell death due to lipid peroxidation

The importance of selenocysteine comes from its role in gene expression and activity of the Se-dependent enzyme, GSH-Px (Floh et al., 1997

(Wu, Y., et al., 2023) At the same time, the products of serine metabolism also undergo changes with aging

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