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Description
Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase
When under oxidative stress (OS) conditions, Hb is oxidized, it binds to the cytoplasmic domain of membrane protein band 3, triggering the formation of aggregates and the covalent linkage of natural anti-band 3 antibodies that may lead to premature RBC removal by splenic macrophages [1, 9]

Balsano, C., Liver-spleen axis in nonalcoholic fatty liver disease
Amino Acids published online, doi:10.1007/s00726-010-0548-9 (16 March 2010)

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female patient with chronic fatigue