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Under anaerobic conditions, pyruvate is converted into lactate via fermentation

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doi: 10.1210/edrv-16-1-3 [DOI] [PubMed] [Google Scholar] 12

207 It must be remembered however, that an increase in lactate synthesis results in acidosis, which may severely damage astrocytes, and by proxy neurones

Methylated UBE2m inhibits PPAR-mediated fatty acid metabolism by neddylating NEDD4 in TECs We further investigated how UBE2m, a key ubiquitin-conjugating enzyme essential for neddylation, regulates NEDD4-mediated PPAR ubiquitination