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It is absorbed in the upper part of the small intestine, is increased with food and delayed on an empty stomach

The so-called Species Sensitivity Distribution (SSD) uses causal relationships between exposure level and effect level of individual species

Typical dosage may range from 1000 mcg once monthly to 1000 mcg several times weekly

Clinical manifestations commonly include abdominal pain, diarrhea (with or without hematochezia), and weight loss