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Here they present a cell-free, multiple hydrogen-bond crosslinked hydrogel loaded with tannic acid and Kartogenin with ultra-durable mechanical properties and stage-dependent drug release behavior to promote cartilage regeneration.

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Nitric oxide signalling pathways

The copper coordination chemistry of GHK-Cu enables controlled cellular delivery of bioavailable copper while simultaneously modulating gene expression patterns, making it a unique multifunctional signaling complex rather than a simple metal chelator