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Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes
Hug G, et al
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Eur.), Calciumhydrogenphosphat-Dihydrat, Lactose-Monohydrat, Hochdisperses Siliciumdioxid, Talkum und Magnesiumstearat (Ph
Furthermore, dysfunctional cholesterol metabolism, mediated by ApoE, particularly the ApoE4 variant, disrupts lipid homeostasis, leading to excessive LDs accumulation in microglia and astrocytes (Qi et al., 2021)
