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There is no scientific evidence that coffee introduced into the colon significantly enhances these natural processes or that it can stimulate glutathione production in clinically meaningful ways

[DOI] [PubMed] [Google Scholar] 163.Li Q, Youn JY, and Cai H

Initially, the older subjects had 55.2% less glycine and 24.4% less cysteine in their red blood cells

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doi: 10.1016/j.biopha.2022.113915 229 LiYZhuXWangKZhuLMurrayMZhouF