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IGF-1, as happens with other hormone therapies (thyroid hormone or insulin), should never been used lightly without firstly assessing its deficiency (local, central or systemic) and secondly by ascertaining that no tumours are near to be generated

In the cohort part Cox proportional hazards models adjusted for age, diagnostic delay, site of onset and ALS-functional rating scale-revised (FRS-R) were applied to calculate hazard ratios (HRs) for overall survival

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Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy