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In macrophages, glutamate activates the NF-B signaling pathway, which upregulates genes related to NOD-like receptor protein 3 (NLRP3) activation

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In addition to their detrimental effects on humans as endocrine disrupting chemicals (EDCs) and carcinogens [8,9,10], PAEs are also toxic to terrestrial and aquatic fauna comprising algae, molluscs, protozoan, crustaceans, invertebrates, and fishes [11]

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