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Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors

The consequences of the cardiovascular disease-related reductions in CBF include accelerated reduction in frontal, parietal, and temporal grey matter volumes (Moroni et al., 2018), cognitive deficits (Jiang et al., 2023), and increased risk of ADRD (Iturria-Medina et al., 2016), particularly in regions vulnerable to early pathology (entorhinal cortex, hippocampus, inferior parietal cortex, inferior temporal cortex) (Mattsson et al., 2014)

Clnica 72 (6), 380385

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Cerebro-spinal fluid (CSF), isolated from the Alzheimer's disease patients when incubated with bromelain leads to decreased level of amyloid-42 monomers and low and oligomers thus bromelain has a strong potential to be used as a therapeutic compound for the treatment of Alzheimer's disease [108]

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