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The nasal spray is typically reserved for maintaining B12 levels after injections bring particularly low levels back to normal (5)

Meienhofer, J

It also helps prevent more problems after heart attacks

Change You May Notice B12 Injection Oral Supplement More energy About 1 to 2 days Several weeks Mental clarity About 3 to 5 days 4 to 6 weeks Mood support About 1 to 2 weeks 1 to 2 months What Affects How Quickly a B12 Shot Works for You If you are comparing notes with a friend and wondering how fast a B12 shot works for them versus you, a few things explain the difference: Your starting levels

For example, semaglutide 2.4mg (Wegovy) has demonstrated approximately 15% weight loss in clinical trials for obesity, while liraglutide 3mg (Saxenda) typically achieves 5-10% weight loss

Always talk to a doctor before starting B12 supplements