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J Physiol Biochem 69:897908

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In addition, later-stage organoids (Day 45) exhibit notable mesenchymal differentiation, expanding the potential applications of iHLOs to studies of complex liver pathologies such as fibrosis

238,239,240 Unlike in murine hepatocytes, the Wnt/-catenin pathway plays an indispensable role in the mitosis of human hepatocytes

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tb , only a small portion of about 5-10% develop the disease in their lifetime (Yoshida et al., 1995
