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When a peptide binds to a receptor and triggers a signal, the cell handles it fine
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This ATF4-mediated induction is often triggered by the GCN2-eIF2 pathway when uncharged tRNAs accumulate (a sign of amino acid deprivation) [23]
Furthermore, other cysteine residues (e.g., Cys226, Cys613, and His225) are involved in the sensing function of Keap1 and are necessary for detecting Cd 2+ , As 3+ , Se 4+ , and Zn 2+ [45, 50]
Signal transduction targeted Ther (2021) 6(1):402
