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Figure 2 There is also now ample evidence demonstrating that insulin reaching the liver via the portal system plays an important role in making the liver more GH sensitive to IGF-I generation ( Effects of disease states on intra-portal insulin levels and changes in the GH/IGF-I axis High GH and low IGF-I Type 1 diabetes is an autoimmune disease characterized by pancreatic -cell destruction leading to intra-portal hypoinsulinemia

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Hockley JR, Taylor TS, Callejo G, Wilbrey AL, Gutteridge A, Bach K, Winchester WJ, Bulmer DC, McMurray G, Smith ES

4.6 Metabolism Plasma, bile, urine, and fecal samples of intact SD rats or BDC rats after a single administration of [3H]BPC157 were analyzed by HPLC combined with a low-energy radionuclide detection technique to obtain the radiometabolite profiles of [3H]BPC157

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