lipid hydroperoxides glutathione Scheme illustrating the generation and fate of in Role of iron, glutathione and
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Furthermore, NRF2 enhances drug resistance by inducing the expression of ATP-binding cassette (ABC) transporters such as ABC sub-family C member 1 (ABCC1) and ABC sub-family G member 2 (ABCG2), which efflux chemotherapeutic agents out of cells

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Glutamate is also necessary for making another neurotransmitter in the brain called gamma-aminobutyric acid

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References (8) Shimizu H1, Kiyohara Y, Kato I, Kitazono T, Tanizaki Y, Kubo M, Ueno H, Ibayashi S, Fujishima M, Iida M

Accumulating evidence points that Nrf2 upregulation can suppress the initiation of ferroptosis (Sun et al., 2016
