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In 2012, Huang et al (85) demonstrated that antiangiogenic treatment influences the effectiveness of immunotherapy by the modulatory activity of antiangiogenic agents on tumor microenvironment

Chlorin e6 loaded by iron oxide NPs linked with glucose significantly enhanced the uptake of Ce6 by lung cancer cells and produced more ROS, damaged the DNA of lung cancer cells, and thereby activated STING and upregulated the expression of IFN-, HMGB1, and HSP90, indicating augmented immunogenicity of lung cancer cells (Yu et al., 2022)

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GHKCu suppresses NFB (including p65 activation) and downstream cytokines such as IL6 and TNF, and simultaneously reduces reactive oxygen species