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When a sleep disturbance is determined to be directly and temporally linked to another mental, physical, or sleep problem, comorbid insomnia is diagnosed (Morin & Benca, 2011).The DSM-5 and ICSD-3 criteria require a subjective report of a sleep complaint (difficulty falling asleep, staying asleep, or waking up early) occurring at least three times a week for three months, along with at least one related daytime impairment (fatigue, attention impairment, mood disturbance, or impaired performance), in order to diagnose chronic insomnia (Saddichha, 2010)

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However, the benefit of anacetrapib in reducing CVE seems to be largely explained by lowering of non-HDL, rather than increases in HDL-C (738)

This Ca 2+ increase is thought to be an underlying mechanism in vascular complications of diabetes (Descorbeth and Anand-Srivastava, 2010)