harmful effects of lipofuscin acetyl l carnitine L-carnitine protects the lung from radiation-induced damage in rats via the AMPK/SIRT1/TGF-1ß pathway | Naunyn-Schmiedeberg's Archives Pharmacology The protective role of l-carnitine
Description
2024;364(Pt 2):125364

It acts as a cofactor that allows functionally necessary transport of long-chain fatty acids into mitochondriathe powerhouses of the cellwhere these fats are oxidized to produce energy

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Physiological values of ROS are required to sustain the signaling pathways controlling crucial cellular processes, among which are inflammation, differentiation, proliferation, homeostasis, and apoptosis, whereas the generation of dysregulated ROS can amplify these same pathways, thus fostering disease phenotypes associated with ROS, as seen in type II diabetes, cancer, and atherosclerosis [19]

however, their efficacy is incomplete, they require repeated administration, and resistance or suboptimal responses are not uncommon
