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Group III (10 patients) received oral placebo capsules (as a control) once daily for 4 weeks

Hyperglycemic state increases the production of di-lipoylglycerol (DAG) (Hayashi and Shirai, 2022), which is an endogenous activator of PKC

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The CpG sites investigated in this study were located near transcription factor binding sites, and hypermethylation of these sites may disrupt MTHFR enzyme functions, thereby affecting Hcy and methionine metabolism [116]

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