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Because a significantly lower incidence of hearing loss was observed in the cisplatin plus STS-treated group, the authors indicated STS as a potential otoprotective agent

On the one hand, by regulating selenocysteine tRNA which in turn promotes GPX4 synthesis

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Jatoi, S., Hafeez, A., Riaz, S

To interrogate the mechanisms underlying NRF2-directed regulation of this core gene set, we compared mean promoter (1 kb restricted) ChIP-seq signal in A549 for NRF2, p300, as well as the histone marks H3K4me3 and H3K27ac, which are enriched at promoters and enhancers, respectively