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These discrepancies underscore that central gain changes in tinnitus are not unidirectional but may depend on factors such as comorbidities (e.g., hyperacusis), insult type, and the specific neural measures employed (Sedley, 2019

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1996;78 Suppl 1:1-24

By inhibiting NNMT activity, 5-Amino-1MQ modulates enzymatic processes associated with nicotinamide metabolism, methylation network regulation, and intracellular cofactor-associated signaling systems

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