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The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

[DOI] [PMC free article] [PubMed] [Google Scholar] Wayne R, Frick K, Neilands JB

Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway

DALYs and mortality related to obesity are the consequence of multiple comorbidities such as cardiovascular (i.e., heart failure) and metabolic diseases (i.e