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Oxidative stress may be one of the contributing factors to these differences [75,76]
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Down S, Kirkland F (2012) Injection technique in insulin therapy
If an antioxidant is not present in sufficient quantity to neutralize ROS, oxidation of biomolecules, like lipid peroxidation, protein damage (carbonylation of aminoalkanoic acid residues), oxidation of single DNA and RNA nucleotides, enzyme inhibition, and activation of apoptosis, will occur (Gill and Tuteja, 2010)
doi: 10.1038/srep11455
