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SLC7A11 localization and function are dynamically regulated by autophagy and lysosomal trafficking 138, 139

With advancing age, reactive oxygen species (ROS) production increases, whereas antioxidant capacity declines, leading to disruption of cellular redox homeostasis and contributing to the development of age-related diseases [6, 7]

As an antioxidant enzyme, GPx1 modulates the balance between necessary and harmful levels of reactive oxygen species

Mol Gen Genomics 272:639650 Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-DeltaC(T)) method

Jinno, N., Nagata, M

Oncogene 34 , 561725 (2015)