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Are phosphodiesterase type 5 inhibitors associated with vision-threatening adverse events

however, the precise signaling pathways and underlying molecular mechanisms remain unclear

Cumulative evidence suggests that both direct inhibitors of ferroptosis, i.e., radical-trapping antioxidants, iron-chelating agents, and activators of the System Xc-/GSH/GPX4 axis, and indirect regulators, i.e., natural compounds and dietary supplements, show promise as anti-ferroptotic agents in promoting ocular cell survival

& Valentin, L

5 Iron is a vital mineral for the human body, and iron metabolism-related molecules including transferrin, metal transporter, and iron response element binding protein 2, can induce ferroptosis by affecting intracellular and systemic iron homeostasis

This finding suggested that luseogliflozin may be more effective in protecting the kidneys during the transition from AKI to CKD than during the acute phase of AKI