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Conversely, ferroptosis related lipid metabolism in tumor microenvironment (TME) affects CD8 + T cell function: arachidonic acid (AA), an 6 polyunsaturated fatty acid transported by CD36, induces ferroptosis in CD8 + T cells, reducing the secretion of IFN, TNF, and perforin (a key effector molecule for tumor cell apoptosis) and ultimately impairing their anti-tumor activity [85, 86]

Exterior images of the entire lung revealed that fibrotic lungs showed red lesion due to interstitial red blood cell leakage caused by tissue damage, whereas the lungs in the healthy group and in the CD5/ LNP treatment group were white (Fig

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