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186 On the other hand, in a randomized controlled trial in 260 men with abnormal sperm number, motility, and morphology, 60 mg of saffron daily for 26 weeks resulted in no differences relative to placebo with regard to sperm density, motility, or morphology, or semen antioxidant capacity

Thioredoxin: Protection from Elevated Blood Glucose Thioredoxin (Trx) is a potent protein disulfide that participates in many thiol-dependent cellular reductive processes and plays an important role in antioxidant defence, signal transduction, and regulation of cell growth and proliferation

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Gut protection: Strong data in rodents demonstrates protection against gut lining injury ( inflammation, epithelial repair) relevant for athletes with high training stress or NSAID exposure

Releases hydroquinone-like activity without the harshness of hydroquinone itself

10.1159/000346968 [DOI] [PubMed] [Google Scholar] EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies) (2015)