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It wouldnt be shocking if a particular threshold of NRF2 activation altered the transcriptome, as some research has demonstrated that some target genes are included in the basal but not the induced NRF2 transcriptome and vice versa

10.1016/0014-5793(95)00906-p 426 MuellerG

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Tian Y, Yang B, Qiu W, Hao Y, Zhang Z, Yang B, et al

Pharmacologic or genetic manipulation of glutathione S-transferase P11 (GSTpi) influences cell proliferation pathways