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The study used 36 male Sprague-Dawley rat pup, exposed to 250 mg/kg PPA to induce ASD-lke features, and pre-treated for 27 days with either yogurt, artichoke extract (400 mg/kg), luteolin (50 mg/kg) or Lacticaseibacillus rhamnosus GG (0.2 mL/day)

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Nutrient combinations In addition to the monotherapies described above, some clinical trials have studied the effects of multi-component nutrient formulations (nutrient combinations)

Gut microbiota in human metabolic health and disease

While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control