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An automatic evaluation for read-across is done, and thus this tool can be used for read across, independently from the prediction obtained through the QSAR models

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The guidance also listed approaches that can improve diversity of enrolled participants, including This Appendix offers a brief overview of trends in diverse enrollment and data reporting across clinical trials, and references lessons-learned and insights from other research related to demographic diversity in trial enrollment

Therapeutic strategies such as hit hard and early and treat-to-target, especially with TNF- inhibitors, can modulate the course of the disease enormously, as they have been shown to lead to drug-free remission, lower disease activity, and higher functional status, which ultimately leads to an improvement in patients quality of life [64,65,66]

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